White man, 79, presented with a painless nodule on his left forearm arising in a tattooed area. He received the 5-cm tattoo more than 50 years earlier.

DIAGNOSIS: Poorly Differentiated Squamous Cell Carcinoma Arising in Tattooed Skin

QUESTION: What is your diagnosis? DS67

DOWNLOAD ANSWER: What is your diagnosis? DS67

COMMENT: Carcinomas within tattooed areas fall into the category of coincidental lesions. To date, all reports of squamous cell carcinoma (SCC) arising from tattoos have been well differentiated or keratoacanthoma/SCC, keratoacanthoma type. Such tumors are usually non aggressive. Of note, keratoacanthomas and keratoacanthoma type SCCs are considered to be the same lesion. Most of the reported cases of tattoo-associated keratoacanthomas and keratoacanthoma type SCCs have occurred within one year after placement of the tattoo, most of them related to red tattoo ink. We found only one reported case of invasive well-differentiated SCC occurring 10 years after a tattoo placement in a 35-year-old man . Our present case appears to be very different than those reported in the literature both clinically and histologically. Our 79-yearold patient developed a poorly differentiated squamous cell carcinoma in a black-tattooed skin more than 50 years after getting the tattoo.

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REF: Sarma DP, Dentlinger RB, Forystek AM, Stevens T, Huerter C.(2010). Poorly differentiated squamous cell carcinoma arising in tattooed skin. Case Reports in Medicine. Case Reports in Medicine, vol. 2010, Article ID 431813, 3 pages, 2010. PubMed PMID: 21274289; PubMed Central PMCID: PMC3027001

Link to publication: Poorly differentiated squamous cell carcinoma arising in tattooed skin