Molluscum contagiosum

M 25, back

 

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Fig 1. Lobular downward proliferation of the squamous epithelial cells. Epidermal cells contain intracytoplasmic eosinophilic (basophilic in the granular layer) inclusion bodies called molluscum bodies. The nuclei are pushed to the periphery by the cytoplasmic inclusions.

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Fig 2. Epidermal cells contain intracytoplasmic eosinophilic (or basophilic in the granular layer) inclusion bodies called molluscum bodies. The nuclei are pushed to the periphery by the cytoplasmic inclusions

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  • Molluscum contagiosum (MC) is a cutaneous infection caused by a large DNA poxvirus, transmitted by direct contact affecting both children and
  • MC pox virus replicates in the cytoplasm of epidermal cells producing cytoplasmic inclusions and enlargement of infected cells.
  • MC is more common in patients on steroid therapy or patients with atopic dermatitis, immunodeficiency, or lymphoproliferative
  • Cup-shaped downward acanthotic lesion showing the suprabasal keratinocytes containing large, prominent, eosinophilic (or basophilic in the granular layer) intracytoplasmic inclusions (molluscum bodies).

Deba P Sarma, MD, Omaha

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