Vulvar  Squamous Cell Carcinoma in-Situ (VIN III)

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  • Dysplasia characterized by epithelial cells with enlarged and hyperchromatic nuclei, high mitotic activity, and dyskeratosis. May involve the skin appendages in 50% of cases. Abnormal mitoses consistently present in VIN 2 and 3
  • VIN I Dysplasia in lower 1/3 of epithelium
  • VIN II Dysplasia in 1/2 to 2/3 of epithelium
  • VIN III Dysplasia greater than 2/3 of epithelium
  • Carcinoma in situ used if there is full thickness change


  • Deba P Sarma, MD, Omaha

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