Nevus lipomatosus cutaneous superficialis (NLCS)


Download: Nevus lipomatosus cutaneous superficialis (Dermolipoma)

M 53, single soft nodule, left thigh

Fig 1.


Fig 2.


  • Normal epidermis, mature adipose tissue in dermis, no encapsulation

Diagnosis: Nevus lipomatosus cutaneous superficialis (Dermolipoma)


Nevus lipomatosus cutaneous superficialis is a rare benign hamartoma characterized by the presence of mature adipose tissue in the dermis.

Clinically, the lesion may be classical type or solitary type. The classical type lesion consists of clusters of papules and nodules usually in the pelvic or gluteal areas occurring at birth or during childhood.

The solitary form occurs as a single dermal nodule or papule after age 20.

Microscopically, superficial and mid dermis show mature adipose tissue in between the dermal collagen. (Remember, normally there is no adipose tissue in the papillary and reticular dermis.)


Nevus (plural: nevi) is a nonspecific medical term for a visible, circumscribed, chronic lesion of the skin or mucosa. The term originates from naevus, which is Latin for “birthmark”.

Melanocytic nevus is a specific lesion  composed of nevus cells of melanocytic lineage whereas  nevus lipomatous cutaneous superficialis is a specific lesion of superficial skin composed of lipocytes (adipocytes or fat cells).

Another thing to remember

Normally, there is no adipocytes in the dermis, but fat cells are the predominant cells of the subcutis. That’s why you may see lipoma or angiolipoma in the subcutis, but not in the dermis.


Deba P Sarma, MD, Omaha