F 48, right index finger

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Diagnosis:
Glomangioma (Glomus tumor, cavernous type)
Comment:

Glomus tumor arises from glomus body (specialized arteriovenous shunt-Sucquet-Hoyer canal seen mostly in fingers and palms). Cell of origin is a modified smooth muscle- glomus cell positive for SMA immunostain.
Painful tumor, mostly in hands and fingers.
Well-circumscribed dermal tumor shows two patterns.
A. Solid pattern:  Mass composed of small vessels with normal endothelial cells surrounded by dense, organoid, mantle of uniform, bland round glomus cells with pale red cytoplasm and central nuclei.
B. Cavernous hemangiomatous pattern, glomangioma (60% of cases): Prominent cavernous vascular pattern with fewer glomus cells found in the vessel wall.