M 58, left chest wall

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Diagnosis:
Granular cell tumor
Comment:

Clinical:
Common dermal tumor in adults, 30-60 yrs, F>M.
Any site, most common: tongue, trunk, limbs.
May be multiple, painful, rarely over 2 cm.

Pathology:
Non-encapsulated, composed of nests of large, oval cells with brightly eosinophilic  granular cytoplasm.
Central or eccentric small, round nuclei.
Overlying epidermis shows acanthosis or pseudoepitheliomatous hyperplasia.
Perineural spread may be present.
Tumor cells are positive for S-100, CD 68, NSE, NKI-C3.
The granules are lysosomes on electron microscopy.
Most granular cells  are neuroectodermal lesions