F 77, asymptomatic dermal papules, both thighs

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Diagnosis:
Granuloma annulare
Comment:

Normal epidermis.

Perivascular and interstitial lymphohistiocytic infiltration.

Mononuclear cells in between the collagen bundles separated by mucinous material stained  blue by Colloidal iron stain.

Histiocytes and multinucleated giant cells around ill-defined hypocellular collagenous tissue.

 

Granuloma annulare (GA) is a benign inflammatory dermatosis of
unknown etiology.
Granuloma annulare is relatively common disease that occurs in all
ages, but it is rare in children. F > M.
Clinically GA presents as dermal papules and annular plaques.
It may be localized (most common), generalized or subcutaneous.
Most cases of GA resolve spontaneously.
GA may be associated with Type 1 diabetes mellitus  and
hematopoietic malignancies (lymphoma and leukemia).