F 42, perianal skin

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Diagnosis:
Hidradenoma papilliferum
Comment:

Hidradenoma papilliferum

Clinical:
In middle aged woman on the pubis, and perineal and perianal skin.

Rarely in upper eyelid and nipple.

Pathology:
– Well circumscribed, encapsulated dermal tumor without any connection to the overlying epidermis.

– Tubular and cystic  epithelial structures with projecting papillary folds lined by one layer of columnar cells with “decapitation” secretion towards the lumen, as seen in apocrine glands.

– There is an outer layer of small cuboidal cells with basophilic nuclei representing myoepithelial cells.

– The tumor is a benign adnexal neoplasm of apocrine gland origin.