Leg, non-healing chronic ulcer
In skin lesions, the cigar-colored fungi are easily seen in hematoxylin and eosin–stained sections. No special stains are needed.
Usual finding is a pseudoepitheliomatous hyperplasia of the epidermis with a diffuse, lymphomononuclear inflammatory infiltrate in the dermis.
Tissue response to the fungus is typically mixed granulomatous and neutrophilic.
Abscesses, granulomas, granulomatous reactions, and abscesses surrounded by a granulomatous reaction with giant cells seen.
Fungal cells may be single, 2-celled, or multiple-celled resulting from multiplication by septation rather than budding